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NV-5138
Item number: Cay35482-1
NV-5138 is a sestrin modulator and mammalian target of rapamycin protein complex 1 (mTORC1) activator. It binds to sestrin 2 (Kd = 1.49 µM) and induces dissociation of sestrin 2 from the multimeric mTORC1 inhibitory complex GATOR2 and mTORC1 activation when used at concentrations ranging from 30 to 100 µM. NV-5138...
| Keywords: | 2S-amino-5,5-difluoro-4,4-dimethyl-pentanoic acid |
| Application: | Sestrin modulator, mTORC1 activator |
| CAS | 2095886-80-7 |
| MW: | 181.2 D |
From 60.00€
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NV-5138
Item number: TGM-T12270-100mg
Description: NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects. Target: mTOR. Smiles: CC(C)(C[C@H](N)C(O)=O)C(F)F. References: Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11,9(1):4107.
| Application: | Sestrin modulator, mTORC1 activator |
| CAS | 2095886-80-7 |
| MW: | 181.18 D |
From 85.00€
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