NSC 59984

NSC 59984 is a reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells. It is reported to induce cell death in colon cancer cells (EC50 = 8.38 µM in p53-null HCT116 cells) without evident toxicity toward normal cells. NSC 59984 has been shown to induce p53 mutant protein degradation via MDM2-mediated ubiquitination.Formal Name: 1-(4-methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one. CAS Number: 803647-40-7. Molecular Formula: C12H15N3O4. Formula Weight: 265.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml, Ethanol: 5 mg/ml. lambdamax: 237, 276, 350 nm. SMILES: CN1CCN(C(/C=C/C2=CC=C([N+]([O-])=O)O2)=O)CC1. InChi Code: InChI=1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+. InChi Key: QKTRIGNWBRHBFV-DUXPYHPUSA-N.