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NSC 59984
Item number: Cay19919-5
NSC 59984 is a reactivator of p53 that restores wild-type p53 signaling by activating p73-dependent apoptosis in mutant p53-expressing colon cancer cells. It is reported to induce cell death in colon cancer cells (EC50 = 8.38 µM in p53-null HCT116 cells) without evident toxicity toward normal cells. NSC 59984 has...
| Keywords: | 1-(4-methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one |
| Application: | p53 pathway activator |
| CAS | 803647-40-7 |
| MW: | 265.3 D |
From 51.00€
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NSC59984
Item number: TGM-T6910-100mg
Description: NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation. Target: p53. Smiles: CN1CCN(CC1)C(=O)\C=C\c1ccc(o1)[N+]([O-])=O. References: Zhang S, et al. Cancer Res. 2015, 75(18), 3842-3852.
| Application: | p53 pathway activator |
| CAS | 803647-40-7 |
| MW: | 265.27 D |
From 60.00€
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