NS 9283

NS 9283 is a positive allosteric modulator of alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human alpha4beta2 subunit-containing nAChRs (EC50 = 4 µM). In vivo, NS 9283 potentiates ABT-594 (Cay-22822) analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia, paw skin incision post-operative pain, and monoiodoacetate-induced osteoarthritis. It reduces nicotine, but not sucrose, self-administration and reinstatement in rats when administered at a dose of 3.5 mg/kg.Formal Name: 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile. CAS Number: 913830-15-6. Molecular Formula: C14H8N4O. Formula Weight: 248.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 3 mg/ml, Ethanol: Partially soluble. lambdamax: 223 nm. SMILES: N#CC1=CC(C2=NC(C3=CN=CC=C3)=NO2)=CC=C1. InChi Code: InChI=1S/C14H8N4O/c15-8-10-3-1-4-11(7-10)14-17-13(18-19-14)12-5-2-6-16-9-12/h1-7,9H. InChi Key: HGFXDSQLRSWUBO-UHFFFAOYSA-N.