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Item number: TGM-T28199-100mg

Description: NS9283, a positive allosteric modulator selective for the alpha4beta2 form, reduces ethanol consumption. Target: AChR. Smiles: C(#N)C=1C=C(C2=NC(=NO2)C=3C=CC=NC3)C=CC1. References: Maurer JJ, et al. Attenuation of nicotine taking and seeking in rats by the stoichiometry-selective alpha4beta2 nicotinic...

Keywords:	NS 9283, NS-9283
Application:	nAChR (alpha4beta2) positive allosteric modulator
CAS	913830-15-6
MW:	248.24 D

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NS 9283

Item number: Cay29189-1

NS 9283 is a positive allosteric modulator of alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs) that potentiates ACh-induced currents in HEK293 cells expressing human alpha4beta2 subunit-containing nAChRs (EC50 = 4 µM). In vivo, NS 9283 potentiates ABT-594 (Cay-22822) analgesic efficacy in...

Keywords:	3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile
Application:	nAChR (alpha4beta2) positive allosteric modulator
CAS	913830-15-6
MW:	248.2 D

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