41 products were found matching "K04813"!

An agonist of alpha4beta2 and alpha6beta2 subunit-containing nAChRs, activates alpha-conotoxin MII-sensitive and -insensitive dopamine release in rat striatal synaptosomes, markers of alpha4beta2 and alpha6beta2 subunit-containing nAChR activation, respectively (EC50s = 12.7 and ~35 nM, respectively), decreases the...

Varenicline is a full agonist of alpha7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs, EC50 = 18 µM) and a partial agonist of alpha4beta2 subunit-containing nAChRs (EC50 = 2.3 µM). Formulations containing varenicline have been used as aids in smoking cessation.Formal Name:...

TMB 8 is a non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs) with IC50 values of 390 and 350 nM, respectively, for human muscle-type and alpha3beta4 subunit-containing ganglionic nAChRs expressed in TE671/RD or SH-SY5Y cells. It inhibits nicotine-induced dopamine release from rat brain...

Varenicline-d4 is intended for use as an internal standard for the quantification of varenicline (Cay-15030) by GC- or LC-MS. Varenicline is a full agonist of alpha7 subunit-containing neuronal nicotinic acetylcholine receptors (nAChRs, EC50 = 18 µM) and a partial agonist of alpha4beta2 subunit-containing nAChRs...

Protein function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. [The UniProt Consortium]

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Cholinergic receptor nicotinic beta 2 Protein function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an...

alpha7 and beta4 nAChR agonist, alpha4beta2 and alpha6beta2 nAChR partial agonist.

Morantel is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs). It enhances channel gating of the alpha3beta2 nAChR subtype by binding to non-canonical sites. Formulations containing morantel are used to treat nematode infections in livestock.Formal Name:...

MG624 is an antagonist of neuronal nicotinic acetylcholine receptors (nAChRs, Ki = 0.055 µM in neuronal chick optic lobe membranes). It is selective for neuronal nAChRs over muscle-type AChRs (Ki = 70 µM in TE671 cells that express muscle-type AChRs). MG624 inhibits currents evoked by acetylcholine in Xenopus...

(±)-Anabasine is an alkaloid that has been found as a minor component in tobacco (Nicotiana). It is a full agonist of nicotinic acetylcholine receptors (nAChRs) that induces depolarization of TE 671 cells endogenously expressing human fetal muscle-type nAChRs (EC50 = 10.1 µM) but not SH-SY5Y cells that primarily...

Hydroxy varenicline is a metabolite of the nicotinic acetylcholine receptor (nAChR) agonist varenicline (Cay-15030).Formal Name: 1,6,7,8,9,10-hexahydro-6,10-methano-2H-pyrazino[2,3-h][3]benzazepin-2-one. CAS Number: 357424-21-6. Synonyms: 2-Hydroxyvarenicline. Molecular Formula: C13H13N3O. Formula Weight: 227.3....

ABT-594 is a potent agonist of neuronal alpha4beta2 subunit-containing nicotinic acetylcholine receptors (nAChRs, Ki = 37 pM in a radioligand binding assay). It is selective for neuronal nAChRs over neuromuscular alpha1beta1deltagamma subunit-containing nAChRs (Ki = 10,000 nM), alpha1B-, alpha2B-, and alpha2C-...