NCT-503

NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 2.5 µM. It has been shown to reduce the production of glucose-derived serine in cells and to suppress the growth of PHGDH-dependent MDA-MB-468 cancer cells both in vitro and in mice bearing orthotopic xenograft tumors.Formal Name: N-(4,6-dimethyl-2-pyridinyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-1-piperazinecarbothioamide. CAS Number: 1916571-90-8. Molecular Formula: C20H23F3N4S. Formula Weight: 408.5. Purity: >98%. Formulation: (Request formulation change), A neat solid. Solubility: :, DMF: 25 mg/mL, DMF:PBS(pH7.2) (1:2): 0.33 mg/mL, DMSO: 10 mg/mL, Ethanol: 1 mg/ml. lambdamax: 284 nm. SMILES: S=C(N1CCN(CC2=CC=C(C(F)(F)F)C=C2)CC1)NC3=NC(C)=CC(C)=C3. InChi Code: InChI=1S/C20H23F3N4S/c1-14-11-15(2)24-18(12-14)25-19(28)27-9-7-26(8-10-27)13-16-3-5-17(6-4-16)20(21,22)23/h3-6,11-12H,7-10,13H2,1-2H3,(H,24,25,28). InChi Key: PJNSZIQUFLWRLH-UHFFFAOYSA-N.