MT-DADMe-ImmA

MT-DADMe-ImmA is an inhibitor of 5'-methylthioadenosine phosphorylase (MTAP, Ki = 1.7 nM). It increases levels of MTA (Cay-15593), a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 µM. MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.Formal Name: (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-3-pyrrolidinol. CAS Number: 653592-04-2. Synonyms: Methylthio-DADMe-Immucillin A, MTDIA. Molecular Formula: C13H19N5OS. Formula Weight: 293.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 231, 279 nm. SMILES: NC1=C2C(C(CN3C[C@H](O)[C@@H](CSC)C3)=CN2)=NC=N1. InChi Code: InChI=1S/C13H19N5OS/c1-20-6-9-4-18(5-10(9)19)3-8-2-15-12-11(8)16-7-17-13(12)14/h2,7,9-10,15,19H,3-6H2,1H3,(H2,14,16,17)/t9-,10+/m1/s1. InChi Key: NTHMDFGHOCNNOE-ZJUUUORDSA-N.