MRX-2843

MRX-2843 is an inhibitor of Mer and FMS-like tyrosine kinase 3 (FLT3, IC50s = 1.3 and 1 nM, respectively). It also inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively). MRX-2843 (10-300 nM) inhibits Mer phosphorylation in MOLM-14 and MV4-11 acute myeloid leukemia (AML) cells and reduces clonal expansion of Kasumi-1 AML cells (IC50 = 143.5 nM). In vivo, MRX-2843 increases survival in NOMO-1 and MOLM-14 AML mouse xenograft models when administered at doses of 65 and 50 mg/kg, respectively.Formal Name: trans-4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol. CAS Number: 1429882-07-4. Molecular Formula: C29H40N6O. Formula Weight: 488.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: soluble. lambdamax: 223, 255, 290 nm. SMILES: CN(CC1)CCN1CC(C=C2)=CC=C2C3=CN([C@@H]4CC[C@@H](O)CC4)C5=NC(NCCC6CC6)=NC=C53. InChi Code: InChI=1S/C29H40N6O/c1-33-14-16-34(17-15-33)19-22-4-6-23(7-5-22)27-20-35(24-8-10-25(36)11-9-24)28-26(27)18-31-29(32-28)30-13-12-21-2-3-21/h4-7,18,20-21,24-25,36H,2-3,8-17,19H2,1H3,(H,30,31,32)/t24-,25-. InChi Key: LBEJYFVJIPQSNX-SOAUALDESA-N.