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MRX-2843
Item number: Cay27923-5
MRX-2843 is an inhibitor of Mer and FMS-like tyrosine kinase 3 (FLT3, IC50s = 1.3 and 1 nM, respectively). It also inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively). MRX-2843 (10-300 nM) inhibits Mer phosphorylation in MOLM-14 and MV4-11 acute myeloid leukemia (AML) cells and reduces clonal expansion of...
| Keywords: | trans-4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclo... |
| Application: | Mer inhibitor, FLT3 inhibitor |
| CAS | 1429882-07-4 |
| MW: | 488.7 D |
From 73.00€
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MRX-2843
Item number: TGM-T16144-100mg
Description: MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively). Target: FLT, Others. Smiles: CN1CCN(Cc2ccc(cc2)-c2cn([C@H]3CC[C@H](O)CC3)c3nc(NCCC4CC4)ncc23)CC1. References: Minson KA, et al. The MERTK/FLT3 inhibitor MRX-2843 overcomes...
| Keywords: | UNC2371 |
| Application: | Mer inhibitor, FLT3 inhibitor |
| CAS | 1429882-07-4 |
| MW: | 488.67 D |
From 56.00€
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