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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay27599-1 | 1 mg | - |
6 - 10 business days* |
158.00€
|
|||
| Cay27599-5 | 5 mg | - |
6 - 10 business days* |
539.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
MRK-560 is a potent inhibitor of gamma-secretase (IC50 = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg)... more
Product information "MRK-560"
MRK-560 is a potent inhibitor of gamma-secretase (IC50 = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-beta (1-40) (Abeta40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Abeta40 levels in rats (ED50s = 6 and 10 mg/kg, respectively). It also decreases brain-soluble Abeta40 and Abeta42 levels and recovers hippocampal long-term potentiation in the Tg2576 transgenic mouse model of Alzheimer's disease.Formal Name: N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-methanesulfonamide. CAS Number: 677772-84-8. Molecular Formula: C19H17ClF5NO4S2. Formula Weight: 517.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM, Ethanol: 50 mM. SMILES: O=S(N[C@H]1CC[C@](S(C2=CC=C(Cl)C=C2)(=O)=O)(C3=C(F)C=CC(F)=C3)CC1)(C(F)(F)F)=O. InChi Code: InChI=1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2/t14-,18+. InChi Key: WDZVWDXOIGQJIO-UJKQEGAGSA-N.
| Keywords: | N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-methanesulfonamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 27599 |
Properties
| Application: | Potent gamma-secretase inhibitor |
| MW: | 517.9 D |
| Formula: | C19H17ClF5NO4S2 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 677772-84-8| Matching products |
| KEGG ID : | K06170 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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