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Item number: Cay27599-1

MRK-560 is a potent inhibitor of gamma-secretase (IC50 = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-beta (1-40) (Abeta40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Abeta40 levels in rats (ED50s = 6 and 10 mg/kg, respectively). It also...

Keywords:	N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoro-methanesulfonamide
Application:	Potent gamma-secretase inhibitor
CAS	677772-84-8
MW:	517.9 D

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MRK-560

Item number: TGM-T16133-100mg

Description: MRK-560 is an effective and brain-penetrant inhibitor of gamma-secretase. Target: Gamma-secretase. Smiles: Fc1ccc(F)c(c1)[C@]1(CC[C@@H](CC1)NS(=O)(=O)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1. References: Best JD, et al. The novel gamma secretase inhibitor...

Application:	Potent gamma-secretase inhibitor
CAS	677772-84-8
MW:	517.92 D

From 34.00€ *

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