46 products were found matching "K06170"!

gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and beta-amyloid precursor protein (APP), within the transmembrane domain. MK-0752 is a potent, reversible inhibitor of gamma-secretase, reducing the cleavage of APP to Abeta40 in human neuroblastoma...

L-685,458 is an inhibitor of gamma-secretase (IC50 = 17 nM). It is selective for gamma-secretase over HIV-1, cathepsin D, trypsin, HepC3 NS3, papain, and calpain I proteases (IC50s = >1,000 nM). L-685,458 inhibits production of amyloid-beta (1-40) (Abeta40, Cay-21617) and Abeta42 (Cay-20574) in Neuro2A cells...

gamma-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and beta-amyloid precursor protein (APP), within the transmembrane domain. Avagacestat is a potent, orally bioavailable inhibitor of gamma-secretase that more potently inhibits the cleavage of APP to...

Semagacestat is a potent inhibitor of gamma-secretase that blocks the production of Abeta38, Abeta40, and Abeta42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively. It also blocks Notch signaling (IC50 = 14.1 nM). Semagacestat modulates gamma-secretase activity in vivo, altering Abeta levels in brain,...

Anti-PEN2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with PEN2 from other sources has not been determined. Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of...

Anti-PEN2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with PEN2 from other sources has not been determined. Protein function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of...

gamma-Secretase inhibitor.

MRK-560 is a potent inhibitor of gamma-secretase (IC50 = 0.65 nM). In vivo, MRK-560 (1-10 mg/kg) reduces diethanolamine-soluble amyloid-beta (1-40) (Abeta40) levels in APP-YAC transgenic mouse brain. MRK-560 reduces brain and cerebrospinal fluid Abeta40 levels in rats (ED50s = 6 and 10 mg/kg, respectively). It also...

CHF5074 is a modulator of gamma-secretase and a derivative of flurbiprofen (Cay-70250). It inhibits the secretion of amyloid beta (1-42) (Abeta42) in H4-APP695NL human neuroglioma cells that overexpress a mutated form of amyloid precursor protein (APP, IC50 = 41 µM) and selectively inhibits secretion of Abeta42 over...

Begacestat is an inhibitor of gamma-secretase that inhibits cleavage of amyloid precursor protein (APP) to amyloid-beta (1-40) (Abeta40, Cay-21617) in vitro (IC50 = 15 nM). It is 14-fold selective for gamma-secretase over Notch-1. Begacestat (5 mg/kg) reduces brain levels of Abeta40 and Abeta42 (Cay-20574) in the...

E2012 is a modulator of gamma-secretase. It selectively inhibits APP intracellular signaling domain (AICD) cleavage to amyloid-beta (Abeta) over Notch cleavage to its signaling effector Notch intracellular domain (NICD), processes both mediated by gamma-secretase, when used at a concentration of 1 µM in luciferase...

NGP-555 is a modulator of gamma-secretase that inhibits APP intracellular signaling domain (AICD) cleavage to amyloid-beta (Abeta, IC50s = 531 and 131 nM for Abeta40 and Abeta42, respectively, in HeLa cell membranes). It is selective for AICD cleavage to Abeta over E-cadherin and Notch cleavage to their signaling...