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MKT-077 is a cationic rhodacyanine dye that demonstrates antiproliferative activity against cancer cell lines (EC50s = 1.4-2.2 µM in vitro) through its ability to inhibit members of the heat shock protein 70 (Hsp70) family of molecular chaperones. It has been shown to bind to an allosteric site conserved in Hsp70 family members, interfering with ATP hydrolysis and abrogating the interaction of the chaperone with the tumor suppressor p53.Formal Name: 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium, monochloride. CAS Number: 147366-41-4. Synonyms: FJ-776. Molecular Formula: C21H22N3OS2 . Cl. Formula Weight: 432.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 2 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 2 mg/ml. lambdamax: 328, 385, 497 nm. SMILES: CN(C1=CC=CC=C1S/2)C2=C3C(N(CC)/C(S\3)=C\C4=CC=CC=[N+]4CC)=O.[Cl-]. InChi Code: InChI=1S/C21H22N3OS2.ClH/c1-4-23-13-9-8-10-15(23)14-18-24(5-2)20(25)19(27-18)21-22(3)16-11-6-7-12-17(16)26-21,/h6-14H,4-5H2,1-3H3,1H/q+1,/p-1/b21-19+,. InChi Key: VSKYOTRJSLYFHX-UXJRWBAGSA-M.
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