Metoprine

Metoprine is an inhibitor of histamine N-methyltransferase (HNMT, IC50 = 91 nM). It is also an inhibitor of dihydrofolate reductase (Dhfr, IC50s = 1, 1. and 60 µM for the chicken, rat, and T. equiperdum enzymes, respectively). Metoprine (10 mg/kg) increases the levels of histamine in mouse cerebral cortex, diencephalon, midbrain, and pons medulla. It decreases the duration of tonic and clonic convulsions in a mouse model of electroshock-induced seizures when administered at doses of 5 or 10 mg/kg. Metoprine (2 or 5 mg/kg) inhibits scopolamine-induced learning deficits in the passive avoidance test in mice.. Solulibility: DMSO: Sparingly soluble: 1-10 mg/ml: Ethanol: Slightly soluble: 0.1- 1 mg/ml.