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Item number: Cay43098-10

Metoprine is an inhibitor of histamine N-methyltransferase (HNMT, IC50 = 91 nM). It is also an inhibitor of dihydrofolate reductase (Dhfr, IC50s = 1, 1. and 60 µM for the chicken, rat, and T. equiperdum enzymes, respectively). Metoprine (10 mg/kg) increases the levels of histamine in mouse cerebral cortex,...

Keywords:	DDMP, NSC 19494, NSC 7364, 5-(3,4-dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
Application:	HNMT inhibitor, antineoplastic
CAS	7761-45-7
MW:	269.13 D

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Metoprine

Item number: TGM-T8548-100mg

Description: Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity. Target: Histone Methyltransferase, Histamine Receptor, Antifolate. Smiles: CC=1C(=C(N)N=C(N)N1)C2=CC(Cl)=C(Cl)C=C2. References: Junichi Kitanaka, et al. Brain Histamine N-Methyltransferase...

Application:	Antineoplastic
CAS	7761-45-7
MW:	269.13 D

From 52.00€ *

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