Mertansine

Mertansine is a thiol-containing derivative of maytansine that is cytotoxic to human epidermoid carcinoma KB and human breast cancer SK-BR-3 cells (IC50 = 1.10 nM for both). Formulations containing mertansine have been studied for the treatment of multiple myeloma and squamous cell carcinoma.Formal Name: N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine. CAS Number: 139504-50-0. Synonyms: DM1 Compound. Molecular Formula: C35H48ClN3O10S. Formula Weight: 738.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMF:PBS (pH7.2) (1:30): 0.03 mg/ml, DMSO: 20 mg/ml, Ethanol: 0.25 mg/ml. lambdamax: 233, 253 nm. SMILES: C[C@@]1([C@@H](O1)[C@H](C)[C@]([H])(C[C@](N2)(O)[C@]([H])(OC)/C=C/C=C(CC3=CC(OC)=C(Cl)C4=C3)\C)OC2=O)[C@@]([H])(OC([C@@H](N(C)C(CCS)=O)C)=O)CC(N4C)=O. InChi Code: InChI=1S/C35H48ClN3O10S/c1-19-10-9-11-26(46-8)35(44)18-25(47-33(43)37-35)20(2)31-34(4,49-31)27(48-32(42)21(3)38(5)28(40)12-13-50)17-29(41)39(6)23-15-22(14-19)16-24(45-7)30(23)36/h9-11,15-16,20-21,25-27,31,44,50H,12-14,17-18H2,1-8H3,(H,37,43)/b11-9+,19-10+/t20-,21+,25+,26-,27+,31+,34+,35+/m1/s1. InChi Key: ANZJBCHSOXCCRQ-FKUXLPTCSA-N.