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Mertansine
Item number: BPS-84307-1
Mertansine, also known as DM1, is a microtubule inhibitor and is an antibody-conjugatable maytansinoid that was developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug...
| Application: | ADC (antibody drug conjugate) preparation |
| CAS | 139504-50-0 |
| MW: | 738.29 D |
From 400.00€
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Mertansine
Item number: Cay22483-25
Mertansine is a thiol-containing derivative of maytansine that is cytotoxic to human epidermoid carcinoma KB and human breast cancer SK-BR-3 cells (IC50 = 1.10 nM for both). Formulations containing mertansine have been studied for the treatment of multiple myeloma and squamous cell carcinoma.Formal Name:...
| Keywords: | DM1 Compound, N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine |
| Application: | Maytansinoid tubulin inhibitor |
| CAS | 139504-50-0 |
| MW: | 738.3 D |
From 144.00€
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Mertansine
Item number: TGM-T1992-100mg
Description: Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. Experimental...
| Keywords: | DM1, Maytansinoid DM1 |
| CAS | 139504-50-0 |
| MW: | 738.29 D |
From 30.00€
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