MDL 72222

A 5-HT3 receptor antagonist (IC50 = 0.82 nM), selective for 5-HT3 over 5-HT1 and 5-HT2 receptors and alpha1-, alpha2-, and beta-adrenergic receptors (IC50s = >10,000 nM for all), as well as the histamine H1 receptor (IC50 = 3,800 nM), intraplantar administration inhibits formalin-induced paw licking and complete Freund's adjuvant-induced decreases in paw withdrawal latency in mice at 10 and 100 µg/animal, inhibits cisplatin-induced emesis in dogs at 0.5 mg/kg