Maytansine

Maytansine is an ansa macrolide originally isolated from M. serrata that has anticancer activity. It inhibits the growth of L1210, L-5178-Y, and P388 murine leukemia cells (EC50s = 0.6, 12, and 1.5 nM, respectively). Maytansine (20 µM) inhibits erythrocyte and brain tubulin polymerization. In vivo, maytansine (0.025-0.1 mg/kg) increases survival in a P388 murine leukemia model. It has also been used in the synthesis of cytotoxic payload moieties of antibody-drug conjugates (ADCs).CAS Number: 35846-53-8. Synonyms: Maitansine, NSC 153858. Molecular Formula: C34H46ClN3O10. Formula Weight: 692.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 10 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): insol. lambdamax: 232, 253 nm. SMILES: C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(C)=O)=O)=O)C)=C(Cl)C(OC)=C4)\C)OC)(NC(O3)=O)O)C)([H])O1. InChi Code: InChI=1S/C34H46ClN3O10/c1-18-11-10-12-26(45-9)34(43)17-25(46-32(42)36-34)19(2)30-33(5,48-30)27(47-31(41)20(3)37(6)21(4)39)16-28(40)38(7)23-14-22(13-18)15-24(44-8)29(23)35/h10-12,14-15,19-20,25-27,30,43H,13,16-17H2,1-9H3,(H,36,42)/b12-10+,18-11+/t19-,20+,25+,26-,27+,30+,33+,34+/m1/s1. InChi Key: WKPWGQKGSOKKOO-RSFHAFMBSA-N. Origin: Synthetic.