LY2795050

LY2795050 is a kappa-opioid receptor antagonist (Ki = 0.722 nM). It is selective for kappa-opioid receptors over µ- and delta-opioid receptors (Kis = 25.8 and 153 nM, respectively). LY2795050 (0.1 mg/kg, i.p.) reduces immobility time in the forced swim test, as well as reduces salvinorin A-induced decreases in grooming time in the splash test, indicating antidepressant-like activity, in mice.Formal Name: 3-chloro-4-[4-[[(2S)-2-(3-pyridinyl)-1-pyrrolidinyl]methyl]phenoxy]-benzamide. CAS Number: 1346133-08-1. Molecular Formula: C23H22ClN3O2. Formula Weight: 407.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. SMILES: NC(C1=CC(Cl)=C(OC2=CC=C(CN3CCC[C@H]3C4=CN=CC=C4)C=C2)C=C1)=O. InChi Code: InChI=1S/C23H22ClN3O2/c24-20-13-17(23(25)28)7-10-22(20)29-19-8-5-16(6-9-19)15-27-12-2-4-21(27)18-3-1-11-26-14-18/h1,3,5-11,13-14,21H,2,4,12,15H2,(H2,25,28)/t21-/m0/s1. InChi Key: LOOCZNLSXJHWTG-NRFANRHFSA-N.