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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
LP99 is a potent inhibitor of the bromodomain containing proteins BRD7 and BRD9 that binds with... more
Product information "LP99"
LP99 is a potent inhibitor of the bromodomain containing proteins BRD7 and BRD9 that binds with Kd values of 99 and 909 nM, respectively, as determined by isothermal titration calorimetry. It is selective for BRD7/9 over a panel of 48 BRDs at concentrations up to 10 µM determined using differential scanning fluorimetry. It inhibits BRD7 interactions with histones H3.3 and H4 with IC50 values of 3.7 and 3.3 µM, respectively, in a bioluminescence resonance energy transfer (BRET) assay in HEK293 cells. Similarly, it inhibits BRD9 from interacting with H3.3 and H4 with IC50 values of 5.1 and 6.2 µM, respectively. It also decreases the level of IL-6 secreted from LPS-stimulated THP-1 cells. See the Structural Genomics Consortium (SGC) website for more information.Formal Name: N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide. CAS Number: 1808951-93-0. Molecular Formula: C26H30ClN3O4S. Formula Weight: 516.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:9): 0.1 mg/ml. lambdamax: 229, 262, 277, 282, 332 nm. SMILES: CC(C1=CC=C(N2C(CC[C@H](NS(CC(C)C)(=O)=O)[C@H]2C3=CC=C(Cl)C=C3)=O)C=C1N4C)=CC4=O. InChi Code: InChI=1S/C26H30ClN3O4S/c1-16(2)15-35(33,34)28-22-11-12-24(31)30(26(22)18-5-7-19(27)8-6-18)20-9-10-21-17(3)13-25(32)29(4)23(21)14-20/h5-10,13-14,16,22,26,28H,11-12,15H2,1-4H3/t22-,26+/m0/s1. InChi Key: LVDRREOUMKACNJ-BKMJKUGQSA-N.
Keywords: | N-[(2R,3S)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 17661 |
Properties
Application: | BRD7/9 bromodomain inhibitor |
MW: | 516.1 D |
Formula: | C26H30ClN3O4S |
Purity: | >98% |
Format: | Crystalline Solid |
Database Information
CAS : | 1808951-93-0| Matching products |
KEGG ID : | K11723 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H315, H317, H319, H335 |
P Phrases: | P261, P264, P270, P271, P272, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P333+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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