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Lisaftoclax
Item number: Cay44963-1
A Bcl-2 inhibitor (Ki = 50s = 0.014-0.384 µM) over those with low Bcl-2 and high Mcl-1 expression (IC50s = 1.11-10.343 µM), induces apoptosis in OCI-LY8 and OCI-Ly19 cells at 5, 10, and 50 nM, induces M2-to-M1 repolarization in TAMs, reduces tumor growth in an OCI-LY8 DLBCL mouse xenograft model at 50 and 100 mg/kg,...
| Keywords: | APG-2575, 4-[4-[[6-(4-chlorophenyl)spiro[3.5]non-6-en-7-yl]... |
| Application: | Bcl-2 inhibitor |
| CAS | 2180923-05-9 |
| MW: | 882.43 D |
From 471.00€
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Lisaftoclax
Item number: TGM-T10483-100mg
Description: Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL) by inhibiting the action of the BCL-2 protein, which promotes the death of...
| Keywords: | APG-2575, Bcl-2/Bcl-xl inhibitor 1 |
| CAS | 2180923-05-9 |
| MW: | 882.42 D |
From 176.00€
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