LCL-521

LCL-521 is an inhibitor of acid ceramidase. It inhibits acid ceramidase activity in MCF-7 breast cancer cell lysates when used at a concentration of 1 µM. LCL-521 (1 and 10 µM) decreases sphingosine levels in MCF-7 cells. It inhibits the proliferation of MCF-7 cells (IC50 = 7.46 µM) and induces cell cycle arrest at the G1 phase when used at a concentration of 2.5 µM.Formal Name: N,N-dimethyl-glycine, 1,1'-[(1R,2R)-1-(4-nitrophenyl)-2-[(1-oxotetradecyl)amino]-1,3-propanediyl] ester. CAS Number: 1226851-11-1. Molecular Formula: C31H52N4O7. Formula Weight: 592.8. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: Slightly Soluble: 0.1-1 mg/ml, Ethanol: Soluble: >10 mg/ml, PBS (pH 7.2): Slightly Soluble: 0.1-1 mg/ml. SMILES: O=C(CN(C)C)O[C@@H]([C@H](NC(CCCCCCCCCCCCC)=O)COC(CN(C)C)=O)C1=CC=C([N+]([O-])=O)C=C1. InChi Code: InChI=1S/C31H52N4O7/c1-6-7-8-9-10-11-12-13-14-15-16-17-28(36)32-27(24-41-29(37)22-33(2)3)31(42-30(38)23-34(4)5)25-18-20-26(21-19-25)35(39)40/h18-21,27,31H,6-17,22-24H2,1-5H3,(H,32,36)/t27-,31-/m1/s1. InChi Key: ANWWJORIPQKJFW-DLFZDVPBSA-N.