56 products were found matching "K12348"!

ARN14974 is a benzoxazolone carboxamide inhibitor of acid ceramidase (IC50 = 79 nM). It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to...

Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil (Cay-14416). It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide (Cay-19556), C16 ceramide...

C12 ceramide is a naturally occurring ceramide that is formed when C12 sphingomyelin is hydrolyzed by acid sphingomyelinase (ASM). It is a substrate for acid ceramidase, an enzyme that has 2- to 12-fold higher activity in fibroblasts from patients with Farber disease, a lipid storage disorder. C12 ceramide is found...

ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide (Cay-24369) and C16 ceramide (Cay-10681) in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and...

LCL-521 is an inhibitor of acid ceramidase. It inhibits acid ceramidase activity in MCF-7 breast cancer cell lysates when used at a concentration of 1 µM. LCL-521 (1 and 10 µM) decreases sphingosine levels in MCF-7 cells. It inhibits the proliferation of MCF-7 cells (IC50 = 7.46 µM) and induces cell cycle arrest at...

SABRAC is an inhibitor of acid ceramidase (IC50 = 52 nM). It is selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 µM. SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50 = 95%. Formulation: (Request formulation change), A solid. Solubility:...

SOCLAC is an irreversible inhibitor of acid ceramidase (Ki = 40.2 nM) and a derivative of the acid ceramidase inhibitor SABRAC (Cay-9003925).Formal Name: 2-chloro-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-acetamide. CAS Number: 126586-82-1. Synonyms: N-chloroacetyl Sphingosine, PKS2. Molecular...

Anti-ASAH1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with ASAH1 from other sources has not been determined. Protein function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. [The UniProt Consortium]

Protein function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. [The UniProt Consortium]

Protein function: Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:7744740, PubMed:15655246, PubMed:11451951). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular...

SOBRAC is an irreversible inhibitor of acid ceramidase (Ki = 29.7 nM) and a derivative of the acid ceramidase inhibitor SABRAC (Cay-9003925).Formal Name: 2-bromo-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-acetamide. CAS Number: 362678-28-2. Molecular Formula: C20H38BrNO3. Formula Weight: 420.4....

SACLAC is an irreversible inhibitor of acid ceramidase (Ki = 97.1 nM) and a derivative of the acid ceramidase inhibitor SABRAC (Cay-9003925). It decreases levels of sphingosine-1-phosphate (S1P) and increases total ceramide levels in OCI-AML-2 acute myeloid leukemia (AML) cells when used at a concentration of 2.5...