LBQ657

LBQ657 is an inhibitor of neprilysin (IC50 = 5 nM). It is selective for neprilysin over angiotensin converting enzyme (ACE) when used at a concentration of 10 µM. LBQ657 inhibits neprilysin cleavage of enkephalin, glutaryl-Ala-Ala-Phe-beta-napthylamide, and atrial natriuretic factor (IC50s = 5, 0.74, and 5.3 nM, respectively).Formal Name: gammaS-[(3-carboxy-1-oxopropyl)amino]-alphaR-methyl-[1,1'-biphenyl]-4-pentanoic acid. CAS Number: 149709-44-4. Synonyms: Sacubitrilat. Molecular Formula: C22H25NO5. Formula Weight: 383.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, Ethanol: 30 mg/mL, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL. lambdamax: 254 nm. SMILES: O=C(CCC(O)=O)N[C@@H](C[C@@H](C)C(O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1. InChi Code: InChI=1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1. InChi Key: DOBNVUFHFMVMDB-BEFAXECRSA-N.