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LBQ657
Item number: Cay19829-1
LBQ657 is an inhibitor of neprilysin (IC50 = 5 nM). It is selective for neprilysin over angiotensin converting enzyme (ACE) when used at a concentration of 10 µM. LBQ657 inhibits neprilysin cleavage of enkephalin, glutaryl-Ala-Ala-Phe-beta-napthylamide, and atrial natriuretic factor (IC50s = 5, 0.74, and 5.3 nM,...
| Keywords: | Sacubitrilat, gammaS-[(3-carboxy-1-oxopropyl)amino]-alphaR-methyl-[1,1'-biphenyl]-4-pentanoic acid |
| Application: | Neprilysin inhibitor |
| CAS | 149709-44-4 |
| MW: | 383.4 D |
From 50.00€
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Sacubitrilat
Item number: TGM-TQ0106-100mg
Description: Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP). Target: Neprilysin. Smiles: C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O)C(O)=O. References: Schiering N, et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci Rep. 2016 Jun...
| Keywords: | LBQ-657 |
| Application: | Neprilysin inhibitor |
| CAS | 149709-44-4 |
| MW: | 383.44 D |
From 39.00€
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