L-threo-Sphingosine C-18

L-threo-Sphingosine C-18
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010541-5 5 mg -

6 - 10 business days*

Cay10010541-10 10 mg -

6 - 10 business days*

Cay10010541-50 50 mg -

6 - 10 business days*

Cay10010541-100 100 mg -

6 - 10 business days*

Sphingosines are long-chain base precursors of cellular sphingolipids and are used directly in... more
Product information "L-threo-Sphingosine C-18"
Sphingosines are long-chain base precursors of cellular sphingolipids and are used directly in the synthesis of ceramide. Sphingosine can exist in four stereoisomers, however only D-erythro-sphingosine occurs naturally. L-threo-Sphingosine C-18, an analog of D-erythro-sphingosine, inhibits protein kinase C in mixed micelle assays with 50% inhibition at 2.2 mol % making it a slightly more potent inhibitor compared to D-erythro-sphingosine (50% inhibition at 2.8 mol %) or other analogs of shorter alkyl chain length. Addition of L-threo-Sphingosine C-18 to primary cultured cerebellar cells does not decrease serine palmitoyltransferase (SPT) activity, the rate-limiting enzyme in ceramide biosynthesis, whereas under similar conditions D-erythro-sphingosine inhibits SPT activity. Formal Name: 2S-amino-4E-octadecene-1,3S-diol. CAS Number: 25695-95-8. Synonyms: L-threo-Sphingosine C18. Molecular Formula: C18H37NO2. Formula Weight: 299.5. Purity: >98%. Formulation: A crystalline solid. Solubility: Ethanol: 0.25 mg/ml. SMILES: CCCCCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO. InChi Code: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18-/m0/s1. InChi Key: WWUZIQQURGPMPG-DNWQSSKHSA-N.
Keywords: L-threo-Sphingosine C18, 2S-amino-4E-octadecene-1,3S-diol
Supplier: Cayman Chemical
Supplier-Nr: 10010541


Application: PKC inhibitor
MW: 299.5 D
Formula: C18H37NO2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 25695-95-8| Find alternatives

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