These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Conversion and usertracking via Google Tag Manager
Sphingosines are long-chain base precursors of cellular sphingolipids and are used directly in the synthesis of ceramide. Sphingosine can exist in four stereoisomers, however only D-erythro-sphingosine occurs naturally. L-threo-Sphingosine C-18, an analog of D-erythro-sphingosine, inhibits protein kinase C in mixed micelle assays with 50% inhibition at 2.2 mol % making it a slightly more potent inhibitor compared to D-erythro-sphingosine (50% inhibition at 2.8 mol %) or other analogs of shorter alkyl chain length. Addition of L-threo-Sphingosine C-18 to primary cultured cerebellar cells does not decrease serine palmitoyltransferase (SPT) activity, the rate-limiting enzyme in ceramide biosynthesis, whereas under similar conditions D-erythro-sphingosine inhibits SPT activity. Formal Name: 2S-amino-4E-octadecene-1,3S-diol. CAS Number: 25695-95-8. Synonyms: L-threo-Sphingosine C18. Molecular Formula: C18H37NO2. Formula Weight: 299.5. Purity: >98%. Formulation: A crystalline solid. Solubility: Ethanol: 0.25 mg/ml. SMILES: CCCCCCCCCCCCC/C=C/[C@H](O)[C@@H](N)CO. InChi Code: InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18-/m0/s1. InChi Key: WWUZIQQURGPMPG-DNWQSSKHSA-N.