L-748,337

L-748,337 is a beta3-adrenergic receptor antagonist that displays selectivity over beta1 and beta2 receptors (Kis = 4, 390, and 204 nM, respectively). It has been shown to couple with Gi to activate MAPK signaling. L-748,337 can inhibit agonist-stimulated lipolysis in rhesus monkey adipocytes, as well as agonist-induced relaxation of smooth muscle.Formal Name: N-[[3-[(2S)-2-hydroxy-3-[[2-[4-[(phenylsulfonyl)amino]phenyl]ethyl]amino]propoxy]phenyl]methyl]-acetamide. CAS Number: 244192-94-7. Molecular Formula: C26H31N3O5S. Formula Weight: 497.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 25 mg/ml, Ethanol: 30 mg/ml, Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml. SMILES: CC(NCC1=CC=CC(OC[C@@H](O)CNCCC2=CC=C(NS(C3=CC=CC=C3)(=O)=O)C=C2)=C1)=O. InChi Code: InChI=1S/C26H31N3O5S/c1-20(30)28-17-22-6-5-7-25(16-22)34-19-24(31)18-27-15-14-21-10-12-23(13-11-21)29-35(32,33)26-8-3-2-4-9-26/h2-13,16,24,27,29,31H,14-15,17-19H2,1H3,(H,28,30)/t24-/m0/s1. InChi Key: AWIONHVPTYTSHZ-DEOSSOPVSA-N.