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Description: L-161982 is a selective antagonist of EP4 receptor. L-161982 could inhibit PGE2-induced ERK phosphorylation and cell proliferation of HCA-7 cells. L-161982 could alleviate collagen-induced arthritis in mice. Target: Prostaglandin Receptor. Smiles: O=C1N(N=C(CCCC)N1CC2=CC=C(C=C2)C3=C(S(NC(=O)C4=C(C)C=CS4)(=O)=O)C=CC=C3)C5=C(C(F)(F)F)C=CC=C5. References: Cherukuri DP, et al. The EP4 receptor antagonist, L-161,982, blocks prostaglandin E2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.Exp Cell Res. 2007 Aug 15,313(14):2969-79.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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