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Isoflurane is an anesthetic most commonly used in veterinary medicine. Isoflurane exhibits cardiomodulatory, neuromodulatory, and pro-inflammatory activities. In diabetic rats, isofluorane decreases cardiac force and intracellular Ca2+ amplitude. Isoflurane also increases IL-6 and NF-kappaB levels in glioma cells and microglia. In other cellular models, isoflurane inhibits L-type voltage-gated Ca2+ channel currents at resting membrane potential. Additionally, isofluorane binds and modulates signaling by ATP synthase and NADH dehydrogenase. Isoflurane also inhibits delayed rectifier and A-type K+ channels and NMDA receptors, activates Ca2+ ATPase and ATP-sensitive K+ channels, and potentiates GABA-A and glycine (GlyR) receptors.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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