Iodophenpropit (hydrobromide)

Iodophenpropit is a histamine H3 receptor antagonist (pA2 = 9.6 in guinea pig intestine, which has a high endogenous expression of H3 receptors). It increases forskolin-induced cAMP production in SK-N-MC cells expressing the recombinant human H3 receptor (EC50 = 25.1 nM). It is also an inhibitor of NR1/NR2A, NR1/NR2B, NR1/NR2C, and NR1/NR2D subunit-containing NMDA receptors (IC50s = 1.3, 1.4, 9.7, and 14 µM, respectively, for the rat recombinant receptors). Iodophenpropit induces scratching behavior in mice when administered intradermally at a dose of 10 nmol and reduces amygdala-kindled seizure duration in rats (ED50 = 2.54 mg/kg).Formal Name: [2-(4-iodophenyl)ethyl]-carbamimidothioic acid, 3-(1H-imidazol-4-yl)propyl ester, dihydrobromide. CAS Number: 145196-87-8. Molecular Formula: C15H19IN4S . 2HBr. Formula Weight: 576.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mg/ml, Water: 50 mg/ml. SMILES: IC1=CC=C(CCNC(SCCCC2=CN=CN2)=N)C=C1.Br.Br. InChi Code: InChI=1S/C15H19IN4S.2BrH/c16-13-5-3-12(4-6-13)7-8-19-15(17)21-9-1-2-14-10-18-11-20-14,,/h3-6,10-11H,1-2,7-9H2,(H2,17,19)(H,18,20),2*1H. InChi Key: BOSOGNBLIWPCMS-UHFFFAOYSA-N.