69 products were found matching "K04151"!

Recombinant CHO-K1 cells stably overexpress human histamine receptor H3 (H3) on the surface and contain high levels of G protein Galphai to couple with the receptor in downstream signaling pathways.

Thioperamide (maleate) is a selective histamine H3 receptor antagonist that crosses the blood-brain barrier. This compound binds to rat cerebral cortical cells in vitro with a pKi value of 8.4 and inhibits histamine binding in vivo with an ED50 value of 1 mg/kg. At a dose of 5 mg/kg thioperamide (maleate) inhibits...

Clobenpropit is a selective histamine H3 receptor antagonist (Ki = 0.17 nM in rat cortical membranes). Clobenpropit (0.3, 0.1, and 3 nM) reduces inhibition of electrically induced contractions in isolated guinea pig ileum longitudinal muscle by the H3 receptor agonist (R)-alpha-methylhistamine (Cay-25601). It does...

R-(-)-alpha-Methylhistamine is a histamine H3 receptor agonist with diverse biological activities. It inhibits the release of histamine induced by antidromic electrical stimulation of the sciatic nerve in rats when administered at doses ranging from 0.25 to 2 mg/kg, an effect that can be reversed by the selective...

Betahistine is a histamine H3 receptor antagonist and histamine H1 receptor agonist. In vivo, betahistine dilates pre-capillary arterioles and increases blood flow to the stria vascularis in guinea pigs. Betahistine (8 mg/kg) reduces weight gain and increased feeding behavior induced by olanzapine (Cay-11937) in...

Conessine is a steroidal alkaloid that has been found in H. antidysenterica and has diverse biological activities. It is active against a variety of Gram-positive and Gram-negative bacteria, including B. subtilis, S. aureus, M. luteus, and E. coli (MICs = 15.6-1,000 µg/disc in agar diffusion assays), the amoeba E....

0.5mg/ml if reconstituted with 0.2ml sterile DI water. The histamine receptor H3(HRH3) is a presynaptic autoreceptor on histamine neurons in the brain and a presynaptic heteroreceptor in nonhistamine-containing neurons in both the central and peripheral nervous systems. The deduced 445-amino acid HRH3 protein...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Histamine H3 receptor Protein function: The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of...

Pitolisant is a nonimidazole histamine H3 receptor antagonist (Ki = 0.16 nM) and inverse agonist (EC50 = 1.5 nM). It increases the levels of tele-methylhistamine in mouse brain, indicating histaminergic neuron activity, with an ED50 value of 1.6 mg/kg. Pitolisant also increases dopamine and acetylcholine levels in...

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an...

JNJ-10181457 is an antagonist of histamine H3 receptors (Kis = 1.17 and 7.08 nM for human and rat receptors, respectively). It increases extracellular norepinephrine and acetylcholine levels in the frontal cortex of rats when administered subcutaneously at a dose of 10 mg/kg. JNJ-10181457 (1.25-10 mg/kg, p.o.)...

Histamine has been implicated in a variety of biological functions including thermo- and immunoregulation, food intake, hyperexcitability, pain transmission, arousal, reward, memory, and emotional responses. The histamine H3 receptor is a Gi-coupled presynaptic auto- and hetero-receptor whose activation leads to a...