IMB-808

An agonist of LXRalpha and LXRbeta, induces transactivation of LXRalpha and LXRbeta in reporter assays using HEK293T cells (EC50s = 0.15 and 0.53 µM, respectively), increases protein levels of ABCG1 and ABCA1 in RAW 264.7 and THP-1 cells at 1 or 10 µM, induces cholesterol efflux and reduces oxidized LDL-induced lipid accumulation in RAW 264.7 cells at 1 or 10 µM. Formulation: A solid. InChI: InChI=1S/C18H15F3N2O4/c1-23(9-15(24)22-12-4-3-11(19)16(20)17(12)21)18(25)10-2-5-13-14(8-10)27-7-6-26-13/h2-5,8H,6-7,9H2,1H3,(H,22,24). InChIKey: XITZPIXICJOKTF-UHFFFAOYSA-N. SMILES: O=C(N(CC(NC1=CC=C(F)C(F)=C1F)=O)C)C2=CC=C3OCCOC3=C2