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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ILK-IN-2 is an inhibitor of integrin-linked kinase (ILK, IC50 = 0.6 µM). It inhibits the... more
Product information "ILK-IN-2"
ILK-IN-2 is an inhibitor of integrin-linked kinase (ILK, IC50 = 0.6 µM). It inhibits the phosphorylation of Akt, glycogen synthase kinase 3beta (GSK3beta), and myosin light-chain (MLC) in PC3 prostate and MDA-MB-231 breast cancer cells when used at concentrations ranging from 1 to 4 µM. ILK-IN-2 inhibits the proliferation of LNCaP, PC3, MDA-MB-231, MDA-MB-468, SK-BR-3, and MCF-7 cancer cells (IC50s = 1.6, 2, 1, 1.5, 1.8, and 2.5 µM, respectively), as well as induces autophagy and apoptosis in PC3 cells when used at a concentration of 2 µM. It also reduces protein levels of Y-box binding protein (YB-1), HER2, and EGFR in PC3 cells. ILK-IN-2 (25 and 50 mg/kg) reduces tumor growth in a PC3 mouse xenograft model.Formal Name: N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-1H-pyrazole-3-propanamide. CAS Number: 1333146-24-9. Synonyms: CPD 22, Integrin-linked Kinase Inhibitor 1, OSU-T 315. Molecular Formula: C30H30F3N5O. Formula Weight: 533.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10mM. lambdamax: 269 nm. SMILES: FC(F)(F)C1=CC=C(C2=CC=C(C3=CC(CCC(NC)=O)=NN3C4=CC=C(N5CCNCC5)C=C4)C=C2)C=C1. InChi Code: InChI=1S/C30H30F3N5O/c1-34-29(39)15-10-25-20-28(38(36-25)27-13-11-26(12-14-27)37-18-16-35-17-19-37)23-4-2-21(3-5-23)22-6-8-24(9-7-22)30(31,32)33/h2-9,11-14,20,35H,10,15-19H2,1H3,(H,34,39). InChi Key: GHBUPSVATJKTRR-UHFFFAOYSA-N.
Keywords: | CPD 22, Integrin-linked Kinase Inhibitor 1, OSU-T 315, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-1H-pyrazole-3-propanamide |
Supplier: | Cayman Chemical |
Supplier-Nr: | 36674 |
Properties
Application: | ILK inhibitor |
MW: | 533.6 D |
Formula: | C30H30F3N5O |
Purity: | >98% |
Format: | Solid |
Database Information
CAS : | 1333146-24-9| Matching products |
KEGG ID : | K06272 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H315, H319, H335 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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