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The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) hydrolyze 2-AG and AEA, respectively, thus terminating their biological function. IDFP is an organophosphorus compound that dually inhibits MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively. At 10 mg/kg, IDFP elevates brain levels of 2-AG and AEA more than 10-fold, and decreases levels of arachidonic acid by a similar magnitude.Formal Name: P-dodecyl-phosphonofluoridic acid, 1-methylethyl ester. CAS Number: 615250-02-7. Synonyms: Isopropyl Dodecylfluorophosphonate. Molecular Formula: C15H32FO2P. Formula Weight: 294.4. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 10 mg/ml, DMSO: 12 mg/ml, Ethanol: 10 mg/ml. SMILES: CCCCCCCCCCCCP(=O)(F)OC(C)C. InChi Code: InChI=1S/C15H32FO2P/c1-4-5-6-7-8-9-10-11-12-13-14-19(16,17)18-15(2)3/h15H,4-14H2,1-3H3. InChi Key: SFRALHFBKRAJPW-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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