GSK690 (hydrochloride)

GSK690 is a lysine-specific demethylase 1 (LSD1) inhibitor (IC50 = 0.09 µM in a cell-free assay). It is selective for LSD1 over monoamine oxidase A (MAO-A, IC50 = >200 µM). GSK690 inhibits LSD1 activity in THP-1 acute myeloid leukemia cells (IC50 = 1.4 µM). GSK690 potentiates reductions in viability of SJCRH30 rhabdomyosarcoma cells induced by the histone deacetylase (HDAC) inhibitor JNJ-26481585 (Cay14088). SMILES: CC(C=C1)=CC=C1C(N=C2)=C(C3=CC=C(C=C3)C#N)C=C2OC[C@@H]4CCNC4.Cl. InChi Code: InChI=1S/C24H23N3O.ClH/c1-17-2-6-21(7-3-17)24-23(20-8-4-18(13-25)5-9-20)12-22(15-27-24)28-16-19-10-11-26-14-19,/h2-9,12,15,19,26H,10-11,14,16H2,1H3,1H/t19-,/m1./s1. InChi Key: DBTSJYXXWZFXNJ-FSRHSHDFSA-N