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SP2509
SP2509

Item number: Cay15487-10

Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression. SP2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM). It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to...
Keywords: HCI-2509, LSD1 Inhibitor VII, 3-(4-morpholinylsulfonyl)-benzoic acid (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide
Application: LSD1 inhibitor
CAS 1423715-09-6
MW: 437.9 D
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Anti-BHC110/LSD1
Anti-BHC110/LSD1

Item number: A300-215A

Protein function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a...
Keywords: Anti-AOF2, Anti-KDM1A, EC=1.-.-.-, Anti-BRAF35-HDAC complex protein BHC110, Anti-Lysine-specific histone demethylase 1A,...
Application: WB, IP, IHC, ChIP-Seq
Reactivity: Human
From 131.00€ *
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ORY-1001
ORY-1001

Item number: Cay19136-1

Lysine-specific demethylase 1 (LSD1) demethylates H3K4 and H3K9, resulting in transcriptional repression. It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370). ORY-1001 is an orally available, selective inhibitor of LSD1 (IC50 < 20 nM). It targets acute...
Keywords: RG-6016, rel-N1-[(1R,2S)-2-phenylcyclopropyl]-1,4-cyclohexanediamine, dihydrochloride
Application: LSD1 inhibitor
CAS 1431326-61-2
MW: 303.3 D
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Tranylcypromine (hydrochloride)
Tranylcypromine (hydrochloride)

Item number: Cay10010494-250

Tranylcypromine is an irreversible, mechanism-based inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 20.7 µM in a cell-free assay). It also irreversibly inhibits monoamine oxidase A (MAO-A) and MAO-B with IC50 values of 2.3 and 0.95 µM, respectively. Tranylcypromine inhibits nucleosomal demethylation of...
Keywords: trans-2-Phenylcyclopropylamine, 2-PCPA, (1R,2S)-rel-2-phenyl-cyclopropanamine, monohydrochloride
Application: LSD1 inhibitor
CAS 1986-47-6
MW: 169.7 D
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LSD1 Inhibitor Screening Assay Kit
LSD1 Inhibitor Screening Assay Kit

Item number: Cay700120-96

Lysine-specific demethylase 1 (LSD1) is a histone demethylase whose actions on specific lysine residues repress transcription of chromosomal DNA. LSD1 also inhibits the tumor suppressor activity of p53 by demethylating a specific lysine residue. Inhibitors of LSD1 are important tools used to elucidate mechanisms of...
Keywords: AOF2, KDM1A, EC=1.-.-.-, BRAF35-HDAC complex protein BHC110, Lysine-specific histone demethylase 1A, Flavin-containing...
Application: LSD1 inhibitor screening
Reactivity: Human
350.00€ *
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GSK-LSD1 (hydrochloride)
GSK-LSD1 (hydrochloride)

Item number: Cay16439-5

Lysine-specific demethylase 1 (LSD1) belongs to the family of flavin adenine dinucleotide (FAD)-dependent amine oxidases that include monoamine oxidases (MAOs) and polyamine oxidase (PAO). LSD1 specifically demethylates mono- and dimethylated histone H3 lysine 4, resulting in transcriptional repression. It also...
Keywords: N-[(1R,2S)-2-phenylcyclopropyl]-4-piperidinamine, dihydrochloride
Application: Irreversible LSD1 inhibitor
CAS 2102933-95-7
MW: 289.2 D
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SP2509
SP2509

Item number: SYN-1212-M001

Soluble in DMSO. LSD1 is a promising target for cancer therapy. Epigenetic control of histone methylation is frequently associated with oncogenesis and LSD1 is overexpressed in many types of cancer. siRNA knockdown of LSD1 has been shown to suppress growth of cancer cells. SP-2528 is a selective and reversible LSD1...
Keywords: SP-2509
Application: LSD1 inhibitor
CAS 1423715-09-6
MW: 437,9 D
From 158.00€ *
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Tranylcypromine (2-PCPA), LSD1 inhibitor
Tranylcypromine (2-PCPA), LSD1 inhibitor

Item number: BPS-27305

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Application: LSD1 inhibitor
CAS 13492-01-8
MW: 364.5 D
389.00€ *
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GSK2879552
GSK2879552

Item number: Cay19403-5

GSK2879552 is a selective, orally bioavailable, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor for element-1-silencing transcription factor (CoREST) activity. Inhibition of LSD1 via GSK2879552 has been shown to enhance H3K4 methylation and to increase the expression of...
Keywords: 4-[[4-[[[(1R,2S)-2-phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]-benzoic acid
Application: LSD1 inhibitor
CAS 1401966-69-5
MW: 364.5 D
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Bizine
Bizine

Item number: Cay19705-5

Bizine is a phenelzine analog that inhibits lysine-specific demethylase 1 (LSD1, Ki(inact) = 59 nM). It is 23-fold, 63-fold, and >100-fold selective for LSD-1 over monoamine oxidase (MAO) A, MAOB, and LSD2, respectively. Bizine has been shown to induce bulk histone H3 lysine 4 dimethylation in LNCaP cancer cells...
Keywords: N-[4-(2-hydrazinylethyl)phenyl]-benzenebutanamide
Application: LSD1 inhibitor
CAS 1591932-50-1
MW: 297.4 D
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LSD1 Chemiluminescent Assay Kit
LSD1 Chemiluminescent Assay Kit

Item number: BPS-50109

The LSD1 Chemiluminescent Assay Kit is designed to directly measure activity of human lysine-specific demethylase (LSD1) for screening and profiling applications. LSD1 is a chromatin-modifying enzyme that specifically removes methyl groups from mono- and dimethylated Lys of histone H3. LSD1 is a critical component...
Keywords: Lysine-specific histone demethylase 1A AOF2, KDM1A, EC=1.-.-.-, BRAF35-HDAC complex protein BHC110, Lysine-specific...
Application: Enzyme kinetics, HTS
625.00€ *
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Anti-BHC110/LSD1 (IHC)
Anti-BHC110/LSD1 (IHC)

Item number: IHC-00122

Protein function: Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a...
Keywords: Anti-AOF2, Anti-KDM1A, EC=1.-.-.-, Anti-BRAF35-HDAC complex protein BHC110, Anti-Lysine-specific histone demethylase 1A,...
Application: IHC
Reactivity: Human
From 131.00€ *
Review
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