GSK_WRN4

A covalent inhibitor of WRN (IC50 = 25 nM), inhibits tumor growth and increases the intratumoral levels of the DNA damage markers p21, phosphorylated gammaH2AX, and phosphorylated KAP-1 in an SW48 mouse xenograft model at 300 mg/kg. SMILES: O=S(C=C[C@H]1NC(C2=CC=C(NC2=O)C3CCCCC3)=O)(C1)=O. InChi Code: InChI=1S/C16H20N2O4S/c19-15(17-12-8-9-23(21,22)10-12)13-6-7-14(18-16(13)20)11-4-2-1-3-5-11/h6-9,11-12H,1-5,10H2,(H,17,19)(H,18,20)/t12-/m1/s1. InChi Key: UUGZQYZJHNKGTI-GFCCVEGCSA-N