55 products were found matching "K10900"!

WRN inhibitor 8 is an inhibitor of the DNA helicase Werner syndrome protein (WRN, IC50 = 48.3 nM). It inhibits the growth of HCT116 and SW480 colorectal cancer cells (GI50s = 0.01699 and 13.64 µM, respectively). SMILES FC(F)(C1CC1)C2=NC=C(C(OC3=CC=CC=C3)=N2)C(N[C@H](/C=C/S(=O)(C)=O)C4CC4)=O InChi Code...

The protein product of the Werners syndrome (WRN) gene is the Werner syndrome ATP-dependent helicase. WRN is part of the ReqQ family of helicases that unwind DNA in preparation for replication, transcription, and repair. WRN appears to play a versatile role in cellular processes including DNA replication,...

The protein product of the Werners syndrome (WRN) gene is the Werner syndrome ATP-dependent helicase. WRN is part of the ReqQ family of helicases that unwind DNA in preparation for replication, transcription, and repair. WRN appears to play a versatile role in cellular processes including DNA replication,...

NSC 617145 is an inhibitor of WRN helicase (IC50 = 230 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only exhibiting 7% inhibition of RECQ1 at a concentration of 5 µM. NSC...

The protein product of the Werners syndrome (WRN) gene is the Werner syndrome ATP-dependent helicase. WRN is part of the ReqQ family of helicases that unwind DNA in preparation for replication, transcription, and repair. WRN appears to play a versatile role in cellular processes including DNA replication,...

Protein function: Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double- stranded DNA. Binds preferentially to DNA substrates...

This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and...

Protein function: Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates...

Recombinant human WRN (Werner syndrome ATP-dependent helicase), encompassing amino acids 517-1093. This construct contains an N-terminal GST-tag followed by a Thrombin cleavage site. The recombinant protein was affinity purified.

The protein product of the Werner's syndrome (WRN) gene is the Werner syndrome ATP-dependent helicase. WRN is part of the ReqQ family of helicases that unwind DNA in preparation for replication, transcription, and repair. WRN appears to play a versatile role in cellular processes including DNA replication,...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 500-946aa. Protein Length: Partial. Tag Info: N-terminal 10xHis-tagged and C-terminal Myc-tagged. Target Protein Sequence: NLGLPTKEEE EDDENEANEG EEDDDKDFLW PAPNEEQVTC LKMYFGHSSF KPVQWKVIHS VLEERRDNVA VMATGYGKSL CFQYPPVYVG KIGLVISPLI SLMEDQVLQL...

Organism: Homo sapiens (Human). Source: E.coli. Expression Region: 500-946aa. Protein Length: Partial. Tag Info: N-terminal 6xHis-tagged. Target Protein Sequence: NLGLPTKEEE EDDENEANEG EEDDDKDFLW PAPNEEQVTC LKMYFGHSSF KPVQWKVIHS VLEERRDNVA VMATGYGKSL CFQYPPVYVG KIGLVISPLI SLMEDQVLQL KMSNIPACFL GSAQSENVLT DIKLGKYRIV...