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Item number: Cay45316-1

A covalent inhibitor of WRN (IC50 = 25 nM), inhibits tumor growth and increases the intratumoral levels of the DNA damage markers p21, phosphorylated gammaH2AX, and phosphorylated KAP-1 in an SW48 mouse xenograft model at 300 mg/kg. SMILES: O=S(C=C[C@H]1NC(C2=CC=C(NC2=O)C3CCCCC3)=O)(C1)=O. InChi Code:...

Keywords:	6-cyclohexyl-N-[(3R)-2,3-dihydro-1,1-dioxido-3-thienyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide
Application:	Covalent WRN (RECQL2/RECQ3) inhibitor
CAS	2923008-66-4
MW:	336.41 D

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