GPX4-IN-6
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
A covalent GPX4 inhibitor (IC50 = 130 nM), inhibits the growth of MDA-MB-468, BT-549, and... more
Product information "GPX4-IN-6"
A covalent GPX4 inhibitor (IC50 = 130 nM), inhibits the growth of MDA-MB-468, BT-549, and MDA-MB-231 cells (IC50s = 12, 3.4, and 8 nM, respectively), increases lipid peroxidation and MDA levels in MDA-MB-231 cells at 10 and 20 µM, decreases mitochondrial volume and induces degradation of mitochondrial crests and outer membranes in MDA-MB-231 cells at 20 µM, reduces tumor volume and weight, without affecting body weight, in an MDA-MB-231 mouse xenograft model at 10 or 20 mg/kg per day. Formulation: A solid. InChI: InChI=1S/C18H17BrFNO5/c1-23-15-8-12(9-16(24-2)18(15)20)21(17(22)10-19)11-3-4-13-14(7-11)26-6-5-25-13/h3-4,7-9H,5-6,10H2,1-2H3. InChIKey: RKMUVAANQXYLLV-UHFFFAOYSA-N. SMILES: O=C(CBr)N(C1=CC(OC)=C(C(OC)=C1)F)C2=CC=C3OCCOC3=C2
| Keywords: | Glutathione Peroxidase 4 Inhibitor 6, Glutathione Peroxidase 4-IN-6, GPX4 Inhibitor 6, 2-bromo-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-N-(4-fluoro-3,5-dimethoxyphenyl)-acetamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43037 |
Properties
| Application: | Covalent GPX4 inhibitor |
| MW: | 426.24 D |
| Formula: | C18H17BrFNO5 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2922824-07-3| Matching products |
| KEGG ID : | K05361 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | -20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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