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GPX4-IN-6
Item number: Cay43037-10
A covalent GPX4 inhibitor (IC50 = 130 nM), inhibits the growth of MDA-MB-468, BT-549, and MDA-MB-231 cells (IC50s = 12, 3.4, and 8 nM, respectively), increases lipid peroxidation and MDA levels in MDA-MB-231 cells at 10 and 20 µM, decreases mitochondrial volume and induces degradation of mitochondrial crests and...
| Keywords: | Glutathione Peroxidase 4 Inhibitor 6, Glutathione Peroxidase 4-IN-6, GPX4 Inhibitor 6,... |
| Application: | Covalent GPX4 inhibitor |
| CAS | 2922824-07-3 |
| MW: | 426.24 D |
From 83.00€
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GPX4-IN-6
Item number: TGM-T77759-100mg
Description: GPX4-IN-6 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 µM) with antitumour activity.GPX4-IN-6 induces ferroptosis and is used for the treatment= and prevention of triple negative breast cancer (TNBC). Target: GPX. Smiles: O=C(N(C1=CC=C2OCCOC2=C1)C3=CC(OC)=C(F)C(OC)=C3)CBr. References: Chen T,...
| CAS | 2922824-07-3 |
| MW: | 426.23 D |
From 60.00€
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