GPX4 Activator 2

GPX4 activator 2 is a ligand for glutathione peroxidase 4 (GPX4, Kd = 0. µM). It inhibits erastin-induced ferroptosis in HT-1080 fibrosarcoma cells (EC50 = 7. µM). GPX4 activator 2 (10 µM) prevents erastin-induced increases in lipid peroxide levels in HT-1080 cells. In vivo, GPX4 activator 2 (25 mg/kg) decreases serum and cardiac levels of malondialdehyde (MDA) and cardiac levels of aspartate aminotransferase (Ast) and reduces myocardial cell degeneration in a mouse model of doxorubicin-induced myocardial injury.. Solulibility: Acetonitrile: Sparingly soluble: 0.1-1 mg/ml: DMSO: Sparingly soluble: 0.1-1 mg/ml.