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Item number: Cay43195-1

GPX4 activator 2 is a ligand for glutathione peroxidase 4 (GPX4, Kd = 0. µM). It inhibits erastin-induced ferroptosis in HT-1080 fibrosarcoma cells (EC50 = 7. µM). GPX4 activator 2 (10 µM) prevents erastin-induced increases in lipid peroxide levels in HT-1080 cells. In vivo, GPX4 activator 2 (25 mg/kg) decreases...

Keywords:	N-(2,4-dimethoxyphenyl)-1-[5-(4-methyl-1-piperazinyl)-1,3,4-thiadiazol-2-yl]-1H-pyrrole-2-methanamine
Application:	GPX4 ligand
CAS	950365-31-8
MW:	414.53 D

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