GNE-317

GNE-317 is a dual inhibitor of PI3Kalpha and the mammalian target of rapamycin (mTOR, apparent Kis = 2 and 9 nM, respectively). It inhibits the proliferation of PC3 prostate cancer and A172 glioblastoma cells with EC50 values of 132 and 240 nM, respectively. GNE-317 (10-40 mg/kg) reduces tumor growth in a U87MG/M glioblastoma mouse xenograft model.Formal Name: 5-[6-(3-methoxy-3-oxetanyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-2-pyrimidinamine. CAS Number: 1394076-92-6. Molecular Formula: C19H22N6O3S. Formula Weight: 414.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: CC1=C(C2(OC)COC2)SC3=C(N4CCOCC4)N=C(C5=CN=C(N)N=C5)N=C31. InChi Code: InChI=1S/C19H22N6O3S/c1-11-13-14(29-15(11)19(26-2)9-28-10-19)17(25-3-5-27-6-4-25)24-16(23-13)12-7-21-18(20)22-8-12/h7-8H,3-6,9-10H2,1-2H3,(H2,20,21,22). InChi Key: XOZLHJMDLKDZAL-UHFFFAOYSA-N.