2 products were found matching "1394076-92-6"!
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GNE-317
Item number: TGM-T6845-100mg
Description: GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB). Target: mTOR, PI3K. Smiles: COC1(COC1)c1sc2c(nc(nc2c1C)-c1cnc(N)nc1)N1CCOCC1. References: Salphati L, et al. Clin Cancer Res. 2012, 18(22):6239-6248
| Keywords: | GNE317 |
| Application: | Dual PI3Kalpha / mTOR inhibitor |
| CAS | 1394076-92-6 |
| MW: | 414.48 D |
From 34.00€
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GNE-317
Item number: Cay27671-10
GNE-317 is a dual inhibitor of PI3Kalpha and the mammalian target of rapamycin (mTOR, apparent Kis = 2 and 9 nM, respectively). It inhibits the proliferation of PC3 prostate cancer and A172 glioblastoma cells with EC50 values of 132 and 240 nM, respectively. GNE-317 (10-40 mg/kg) reduces tumor growth in a U87MG/M...
| Keywords: | 5-[6-(3-methoxy-3-oxetanyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-2-pyrimidinamine |
| Application: | Dual PI3Kalpha / mTOR inhibitor |
| CAS | 1394076-92-6 |
| MW: | 414.5 D |
From 53.00€
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