GFB-8438
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
GFB-8438 is an inhibitor of transient receptor potential canonical 5 (TRPC5, IC50 = 0. µM). It is... more
Product information "GFB-8438"
GFB-8438 is an inhibitor of transient receptor potential canonical 5 (TRPC5, IC50 = 0. µM). It is selective for TRPC5 over TRPC6 and voltage-gated sodium channel 1. (Nav1.5, IC50s = >30 µM for both) and a panel of 100 receptors and kinases at 10 µM but does inhibit TRPC4 (IC50 = 0. µM). GFB-8438 (30 mg/kg per day) decreases urinary excretion of total protein and albumin in a rat model of high salt- and unilateral nephrectomy-induced renal hypertension.. Solulibility: DMSO: Sparingly soluble: 1-10 mg/ml: Ethanol: Slightly soluble: 0.1-1 mg/ml.
| Keywords: | 4-chloro-5-[3-oxo-4-[[2-(trifluoromethyl)phenyl]methyl]-1-piperazinyl]-3(2H)-pyridazinone |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43035 |
Properties
| Application: | TRPC5 inhibitor |
| MW: | 386.76 D |
| Formula: | C16H14ClF3N4O2 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2304549-73-1| Matching products |
| KEGG ID : | K04968 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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