20 products were found matching "K04968"!

AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5, IC50 = 14.7 µM). It is selective for TRPC5 over TRPC4 and TRPC6 at concentrations up to 100 and 30 µM, respectively. It inhibits TRPC5 in a concentration-dependent manner in HEK293 cells when used at concentrations ranging from 1 to...

Protein function: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by...

Anti-TrpC5 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with TrpC5 from human, mouse, and rat based on 100% homology with the immunizing sequence. Cross-reactivity with TrpC5 from other sources has not been determined. Ion Channels research. Protein...

TRPC5, NS4B, histamine H1 inhibitor.

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Short transient receptor potential channel 5 (TrpC5), also known as TRP-5, is a protein that in humans is encoded by the TRPC5 gene. It is subtype of the TRPC family of mammalian transient receptor potential ion channels. The predicted 973-amino acid TRPC5...

Clemizole is an antihistamine that antagonizes the histamine 1 receptor at high nanomolar concentrations. It less potently blocks transient receptor potential canonical channel 5 (TRPC5, IC50 = 1.0-1.3 µM), with at least 6-fold selectivity for TRPC5 over other TRP channels. Clemizole also has hepatitis C antiviral...

Description: AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss. Target: TRP/TRPV Channel. Smiles: C(Nc1nc2ccccc2n1Cc1ccccc1)c1ccco1. References: Yiming Zhou, et al. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive...

Description: Clemizole hydrochloride is an antagonist for H1 histamine receptor. According to the research, Clemizole hydrochloride can inhibit hepatitis C virus (HCV) replication and NS4B's RNA binding. Target: HCV Protease, Histamine Receptor. Smiles: Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc23)cc1.Cl. References: Einav S,...

GFB-8438 is an inhibitor of transient receptor potential canonical 5 (TRPC5, IC50 = 0. µM). It is selective for TRPC5 over TRPC6 and voltage-gated sodium channel 1. (Nav1.5, IC50s = >30 µM for both) and a panel of 100 receptors and kinases at 10 µM but does inhibit TRPC4 (IC50 = 0. µM). GFB-8438 (30 mg/kg per day)...

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....

Primers are provided as a 40 µl solution containing both primers at a final concentration of 50 µM in 10 mM Tris-HCl (pH 7.5), 0.1 mM EDTA. Dilute with water as needed prior to use. This amount is sufficient for 1000 x 20µl PCR reactions assuming a final primer concentration of 0.1 µM. Add cDNA template....