Garcinoic Acid

Garcinoic acid is a derivative of vitamin E originally isolated from C. grandiflora. It inhibits IL-1beta-induced microsomal prostaglandin E2 synthase-1 (mPGES-1) activity in A549 cells when used at concentrations of 1 and 10 µM. It has higher antioxidant activity relative to (±)-alpha-tocopherol (Cay-25985) in a cell-free assay when used at a concentration of 0.15 mM.Formal Name: (2E,6E,10E)-13-[(2R)-3,4-dihydro-6-hydroxy-2,8-dimethyl-2H-1-benzopyran-2-yl]-2,6,10-trimethyl-2,6,10-tridecatrienoic acid. CAS Number: 91893-83-3. Synonyms: delta-Garcinoic Acid, delta-trans-Tocotrienoloic Acid. Molecular Formula: C27H38O4. Formula Weight: 426.6. Purity: >98%. Formulation: (Request formulation change), A film. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 30 mg/ml. SMILES: OC1=CC(C)=C2C(CC[C@](CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C(O)=O)(C)O2)=C1. InChi Code: InChI=1S/C27H38O4/c1-19(11-7-13-21(3)26(29)30)9-6-10-20(2)12-8-15-27(5)16-14-23-18-24(28)17-22(4)25(23)31-27/h9,12-13,17-18,28H,6-8,10-11,14-16H2,1-5H3,(H,29,30)/b19-9+,20-12+,21-13+/t27-/m1/s1. InChi Key: QOFWRHWADNWKSU-LRXIOGKNSA-N. Origin: Plant/Garcinia kola nut.